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Riscul aparitiei unor astfel de manifestari creste in cazul consumului concomitent de alcool, al asocierii cu alte medicamente deprimante ale sistemului nervos sau in cazul utilizarii de doze mai mari de Imovane seven,five mg decat doza maxima recomandata.dependenta fizica  si  psihica, chiar  la  dozele terapeutice, cu  sindrom de  abstinent